I have been dealing with NVIDIA driver issues on my Linux PC because my 1080 was good enough to play my favorite games. A very sincere fuck you to NVIDIA.

I chose EndeavourOS initially because I was relatively new to Linux (I tinkered with Ubuntu in grade school) and wanted out of Microsoft’s environment. The support community is amazing and newbie-friendly. They’ve helped me through a few bricked systems.

Now I’m at a crux because I own a 1080 and am tired of mistakenly breaking my installation because NVIDIA stopped supporting open source drivers for old cards. I felt uncomfortable building my own driver packages and was relying on AUR, but the recent security breach has me skittish.

Rather than switch to another distro (Mint being the top contender), I decided to replace my graphics card and stay with Endeavour because it seems the Arch distros are the only ones staunchly against age verification laws. I’m fortunate enough to be in a position to update and stick with Endeavour. Maybe when I actually get good at Linux I’ll switch to pure Arch.

Holy crap, you’re right! Fixed it

I can’t get any banking apps to work. I just use their web version in a pinch. Only loss I’ve experienced.

X4 is an economy simulator masquerading as a flight simulator. It also goes on sale regularly!

Me and two friends were coincidentally summoned at the same time - 3 different counties across two states. Mine and one of my friend’s summons were cancelled, and my other friend just got sent home yesterday from a case as he wasn’t needed. But the position has tenure for 3-4 months so we might have to go back.

Monster Train 2. I have 1 more challenge run left before reaching 100% completion of those. Then I might finally pick up the DLC and try to finish 100% of clan combos at max crucible level.

Only then will I allow myself to pick up Slay the Spire 2. I try to avoid early access games, but will make an exception here.

In MT1 last month, I beat 100% class combos at C20. The challenges were less fun because they required you to play at C20, and I felt like that difficulty permanently limited what strategies were viable. Challenges in 2 are zanier and most are at a lower difficulty, so it’s altogether more fun.

It gets better - the local minor league baseball team is called the Florence Y’alls. And their mascot is a water tower. It’s so Midwest.

By the time I finished graduate school, reddit was dead so I never bothered getting verified on the Science subreddits. It was a bummer!

I’ll be the pedant no one asked for - the sodium and potassium channels in the neuron respond to voltage changes in the membrane, so the author isn’t wrong.

Action potentials are generated when dendritic (input) channels bind with neurotransmitters like glutamate and GABA released by the axon terminal (output) of the pre-synapse cell. When these channels open, the let in ions like Calcium, Sodium, and Chloride.

These ions change the electric potential across the cell membrane, once this passes a key threshold, the sodium channels in the rest of the cell open up and generate an action potential. It’s driven by ions with electric charge (electrochemical).

Not quite, an iron lung replaces a dysfunctional organ. I’m saying we can already grow neurons onto circuits, and it’s difficult (not impossible) to implant neurons into a body. I don’t easily see how these bio-engineered neurons make those processes easier.

Credentials: I published in this field, but I don’t have time to read the entire paper right now.

This is exciting work. Based on the key highlights, it sounds like their work focuses on how plausible it is to construct the bio-artificial neuron, and they have done so with great success.

What I would like to learn about is what advantages this technology has compared to just cultivating neurons on a microelectrode array. Are the artificial cells easier to maintain? Do they interface with electrodes without developing glial scarring like our brains do? Can they bio-engineer special proteins (e.g. optogenetic channels) easier in these cells than in mouse lines?

The discussion section is fairly anemic. The authors say this will “spearhead” additional development but I was disappointed the authors didn’t clarify what will be additionally developed.

Until these advantages are spelled out, it feels like we’re re-invented the biological wheel. We already have cells that can integrate and fire at low voltages. They’re called neurons. Why did we need artificial ones?

I was about that age when I was gifted a microscope. No idea if you can still find them that cheap, though

This happened with an academic conference (physics iirc). A professor was asked to speak and she submitted a headshot for use in their advertising, but the conference wanted a different aspect ratio. Rather than crop the image, the materials designer asked ChatGPT to expand the photo to the correct size. It gave the professor a low cut shirt, and no one at the conference company noticed until the promotional materials were distributed and the professor contacted them.

I’ve been watching this treatment for a while, in my opinion it’s one of the most exciting development in modern medicine. It represents a lot of potential - Huntington’s is one of many brain diseases related to protein aggregates, so this technology could be adapted to other diseases. Plus, this is the first curative treatment for what was otherwise a 100% fatal genetic condition.

Ah, the old effect size vs significance issue, thanks for clarifying. I perused the link you sent, I didn’t do a deep dive. The authors could have used more precise language.

Here’s a second paper from 2017, https://eprints.gla.ac.uk/151483/1/151483.pdf , which looks at duration of breastfeeding and SIDS. Not sure if you’ve come across it, but I was surprised to see the potential protective factors don’t begin until breastfeeding has gone on for at least 2 months.

Unfortunately I think the odds that we get a randomized clinical trial looking at breast vs formula are low - I didn’t find one in my brief Google Scholar search, but I’m also not a pediatrician.

But, ultimately, the first link i provided includes breastfeeding as part of a larger suite of recommendations for co-sleeping that, if all are followed, bring the risk of SIDS down to a comparable rate with modern safe sleep recommendations.

I’ll agree that there’s a lot of conflicting information when it comes to parenting, it’s called the mommy wars for a reason. But, I’ll disagree with you that I provides pseudoscience. I’ll direct you specifically to references 11 through 13 in the link I provided. They are dated, but peer-reviewed.

I’m also confused by your link, it appears to be a meta-analysis which “found ample evidence that both breastfeeding and [pacifier] use reduced the risk of SIDS.”

Overall, I like Cribsheet’s stance again - the best baby is a fed baby, the difference between a breastfed baby and a formula-fed baby are very minor and do not result in any persistent, dramatic differences.

Surprisingly, that’s not the entire story of SIDS - but it is one of the biggest contributing factors to why co-sleeping can be unsafe. It’s also why alcohol consumption dramatically increases the dangers.

I’ll plug some work done by La Leche League, a non-profit that provides resources for breastfeeding mothers. Now, this resource is for babies who are entirely breastfed - no bottles whatsoever - so it’s not for everyone unfortunately.

Their research has shown seven factors that, if addressed, can reduce the risk of SIDS in co-sleeping arrangements to be equal to modern safe sleep arrangements. https://llli.org/news/the-safe-sleep-seven/

I would also encourage people to read Cribsheet, which provides a fantastic deep dive into the specifics of SIDS risk. Understanding more about SIDS, and learning why safe sleep guidance exist, put my mind at ease as a new parent.

I forget the name of the app, but we used a potty tracker. Basically, once we realized our puppy went to the bathroom X hours after eating or drinking, we took him outside a few minutes before then.

I’ve also heard you can take those pee pads and gradually move them closer to the door until they’re outside.